High-efficiency aminocarbonylation by introducing CO to a pressurized continuous flow reactor

被引：70

作者：

Csajagi, Csaba ^{[1
]}

Borcsek, Bernadett ^{[1
]}

Niesz, Krisztian ^{[1
]}

Kovacs, Ildiko ^{[1
]}

Szekelyhidi, Zsolt ^{[1
]}

Bajko, Zoltan ^{[1
]}

Urge, Laszlo ^{[1
]}

Darvas, Ferenc ^{[1
]}

机构：

[1] ThalesNano Inc, H-1031 Budapest, Hungary

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 08期

关键词：

D O I：

10.1021/ol7030894

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzed aminocarbonylation in a micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and high temperature with CO gas introduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) were rapidly optimized in the reactions, which required less than 2 min. The method gave improved results over comparable batch techniques and is also suited to automated parallel syntheses of compound libraries.

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页码：1589 / 1592

页数：4

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