Getting hydrophilic compounds into cells: Lessons from homeopeptides - Commentary

被引：183

作者：

Prochiantz, A

机构：

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(96)80095-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The homeodomain of Antennapedia, a Drosophila transcription factor, translocates across biological membranes. Within this 60-amino-acid polypeptide, a shorter sequence of 16 amino acids was identified that can be used as an internalization vector for several types of cargo (i.e. other peptides and oligonucleotides) into the cytoplasm and nucleus of all cell types. This article describes our present understanding of this phenomenon and discusses its potential applications in cell biology.

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页码：629 / 634

页数：6

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