Amifostine (Ethyol(R)): Dosing, administration and patient management guidelines

被引：36

作者：

Bukowski, RM

机构：

[1] Experimental Therapeutics Program, The Cleveland Clinic Foundation, Department of Hematology/Oncology, Cleveland, OH 44195-5237

来源：

EUROPEAN JOURNAL OF CANCER | 1996年 / 32A卷

关键词：

amifostine; administration guidelines; cancer;

D O I：

10.1016/S0959-8049(96)00328-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytoprotection utilising amifostine (Ethyol(R), WR-2721) is an evolving strategy to protect normal cells from the toxicity of chemotherapy. The dosing and administration guidelines are reviewed. The recommended dose of amifostine is 910 mg/m(2) as a 15-min infusion prior to chemotherapy. Toxicity of this agent is moderate with hypotension and nausea/vomiting being observed in variable numbers of patients. Administration of amifostine with chemotherapy is simple and is associated with acceptable toxicity. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：S46 / S49

页数：4

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