Detection of antibodies to toxin-coregulated pili in sera from cholera patients

被引：11

作者：

Attridge, SR ^{[1
]}

Wallerström, G

Qadri, F

Svennerholm, AM

机构：

[1] Univ Adelaide, Dept Mol Biosci, Adelaide, SA 5005, Australia

[2] Univ Gothenburg, Dept Med Microbiol & Immunol, Gothenburg, Sweden

[3] Int Ctr Diarrhoeal Dis Res, Ctr Hlth & Populat Res, Dhaka 1000, Bangladesh

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 03期

关键词：

D O I：

10.1128/IAI.72.3.1824-1827.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibodies (MAbs) were prepared against toxin-coregulated pili (TCP) isolated from Vibrio cholerae O1 El Tor. Despite their limited bactericidal potential, two MAbs were able to mediate biotype-specific protection against experimental cholera in infant mice. These MAbs were used in immunoblotting studies to assess seroconversion to El Tor TCP following cholera. Clear anti-pilus responses were observed in five of nine patients.

引用

页码：1824 / 1827

页数：4

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