Genetic characterization of H1N1, H1N2 and H3N2 swine influenza virus in Thailand

被引:38
作者
Chutinimitkul, Salin [1 ]
Thippamom, Nattakarn [2 ]
Damrongwatanapokin, Sudarat [3 ]
Payungporn, Sunchai [1 ]
Thanawongnuwech, Roongroje [2 ]
Amonsin, Alongkorn [2 ]
Boonsuk, Pitirat [1 ]
Sreta, Donruethai [2 ]
Bunpong, Napawan [2 ]
Tantilertcharoen, Rachod [2 ]
Chamnanpood, Pornchai [3 ]
Parchariyanon, Sujira [3 ]
Theamboonlers, Apiradee [1 ]
Poovorawan, Yong [1 ]
机构
[1] Chulalongkorn Univ, Ctr Excellence Clin Virol, Dept Pediat, Fac Med, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Vet Sci, Bangkok 10330, Thailand
[3] Natl Inst Anim Hlth, Dept Livestock Dev, Bangkok 10330, Thailand
关键词
D O I
10.1007/s00705-008-0097-7
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Swine have been known to be a suitable host for influenza A virus. In Thailand, phylogenetic analysis on swine influenza virus (SIV) has as yet not been attempted. The present report presents molecular and phylogenetic analysis performed on SIV in Thailand. In this study, 12 SIV isolates from the central and eastern part of Thailand were subtyped and the molecular genetics of hemagglutinin and neuraminidase were elucidated. Three subtypes, H1N1, H1N2 and H3N2, are described. Phylogenetic analysis of the SIV hemagglutinin and neuraminidase genes shows individual clusters with swine, human or avian influenza virus at various global locations. Furthermore, amino acid substitutions were detected either at the receptor binding site or the antigenic sites of the hemagglutinin gene.
引用
收藏
页码:1049 / 1056
页数:8
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