Escape from X inactivation

被引：90

作者：

Disteche, CM

Filippova, GN

Tsuchiya, KD

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Med, Seattle, WA 98195 USA

[3] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98104 USA

[4] Vanderbilt Univ, Div Med Genet, Nashville, TN USA

来源：

CYTOGENETIC AND GENOME RESEARCH | 2002年 / 99卷 / 1-4期

关键词：

D O I：

10.1159/000071572

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off. In this review, we will discuss evolutionary aspects of escape from X inactivation, in relation to the divergence of the sex chromosomes. Molecular characteristics, expression, and epigenetic modifications of genes that escape will be presented, including their developmental regulation and the implications of chromatin domains along the X chromosome in modeling the escape process. Copyright (C) 2002 S. Karger AG, Basel.

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页码：36 / 43

页数：8

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