Can farm milk consumption prevent allergic diseases?

被引:85
作者
Braun-Fahrlaender, C. [1 ,2 ]
von Mutius, E. [3 ]
机构
[1] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland
[2] Univ Basel, Fac Med, Basel, Switzerland
[3] Univ Munich, Dr von Haunerschen Childrens Hosp, Munich, Germany
关键词
allergy; asthma; epidemiology; farm milk; milk components; POLYUNSATURATED FATTY-ACIDS; CONJUGATED LINOLEIC ACIDS; COWS MILK; BREAST-MILK; INVERSE ASSOCIATION; HEALTH PROPERTIES; RAW-MILK; TGF-BETA; ASTHMA; WHEY;
D O I
10.1111/j.1365-2222.2010.03665.x
中图分类号
R392 [医学免疫学];
学科分类号
100108 [医学免疫学];
摘要
P>Cow's milk is an important part of human diet and a source of food allergy for some individuals. Medical guidance strongly discourages consumption of raw milk because of the known health risk associated with pathogenic bacteria present in unpasteurized milk. Despite these risks there is a growing body of epidemiological evidence suggesting that consumption of unprocessed cow's milk does not increase but rather decreases the risk of asthma, hay fever and atopic sensitisation. The article reviews the epidemiological literature and discusses components of unprocessed milk potentially responsible for this protection. It focuses on the role of bacteria in raw milk, the fatty acid profile, whey proteins and finally the role of allergens in milk. Although the epidemiological evidence consistently suggest a protective role of unprocessed cow's milk consumption on the development of asthma, hay fever and atopic sensitization the underlying mechanisms are not yet understood and the consumption of raw milk cannot be recommended as a preventive measure for allergic diseases. Cite this as: C. Braun-Fahrlander and E. von Mutius, Clinical & Experimental Allergy, 2011 (41) 29-35.
引用
收藏
页码:29 / 35
页数:7
相关论文
共 47 条
[1]
Allerberger Franz, 2003, International Journal of Infectious Diseases, V7, P42, DOI 10.1016/S1201-9712(03)90041-5
[2]
Orally administered TGF-β is biologically active in the intestinal mucosa and enhances oral tolerance [J].
Ando, Takashi ;
Hatsushika, Kyosuke ;
Wako, Masanori ;
Ohba, Tetsuro ;
Koyama, Kensuke ;
Ohnuma, Yuko ;
Katoh, Ryohei ;
Ogawa, Hideoki ;
Okumura, Ko ;
Luo, Jian ;
Wyss-Coray, Tony ;
Nakao, Atsuhito .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (04) :916-923
[3]
Crete: does farming explain urban and rural differences in atopy? [J].
Barnes, M ;
Cullinan, P ;
Athanasaki, P ;
Macneill, S ;
Hole, AM ;
Harris, J ;
Kalogeraki, S ;
Chatzinikolaou, M ;
Drakonakis, N ;
Bibaki-Liakou, V ;
Taylor, AJN ;
Bibakis, I .
CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (12) :1822-1828
[4]
Maternal dietary alpine butter intake affects human milk:: Fatty acids and conjugated linoleic acid isomers [J].
Bertschi, I ;
Collomb, M ;
Rist, L ;
Eberhard, P ;
Sieber, R ;
Bütikofer, U ;
Wechsler, D ;
Folkers, G ;
von Mandach, U .
LIPIDS, 2005, 40 (06) :581-587
[5]
Biological effects of conjugated linoleic acids in health and disease [J].
Bhattacharya, Arunabh ;
Banu, Jameela ;
Rahman, Mizanur ;
Causey, Jennifer ;
Fernandes, Gabriel .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2006, 17 (12) :789-810
[6]
A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expression [J].
Bieli, Christian ;
Eder, Waltraud ;
Frei, Remo ;
Braun-Fahrlaender, Charlotte ;
Klimecki, Walt ;
Waser, Marco ;
Riedler, Josef ;
von Mutius, Erika ;
Scheynius, Annika ;
Pershagen, Goran ;
Doekes, Gert ;
Lauener, Roger ;
Martinez, Fernando D. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (06) :1308-1315
[7]
Dietary fat and asthma: Is there a connection? [J].
Black, PN ;
Sharpe, S .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (01) :6-12
[8]
Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale [J].
Calder, Philip C. .
BIOCHIMIE, 2009, 91 (06) :791-795
[9]
Fatty acid composition of mountain milk from Switzerland:: Comparison of organic and integrated farming systems [J].
Collomb, Marius ;
Bisig, Walter ;
Buetikofer, Ueli ;
Sieber, Robert ;
Bregy, Mirjam ;
Etter, Luzi .
INTERNATIONAL DAIRY JOURNAL, 2008, 18 (10-11) :976-982
[10]
Microbiological composition of raw milk from selected farms in the Camembert region of Normandy [J].
Desmasures, N ;
Bazin, F ;
Gueguen, M .
JOURNAL OF APPLIED MICROBIOLOGY, 1997, 83 (01) :53-58