Artemisinin mediated alteration of haemin to a δ-meso oxidation product:: relevance to mechanism of action

被引：9

作者：

Bharel, S

Vishwakarma, RA ^{[1
]}

Jain, SK

机构：

[1] Natl Inst Immunol, Bioorgan Chem Lab, New Delhi 110067, India

[2] Hamdard Univ, Dept Biochem, New Delhi 110062, India

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 14期

关键词：

D O I：

10.1039/a802423e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Antimalarial drug artemisinin and haemin react in vitro, to give a delta-mese hydroxy porphyrin isolated as a stable dimethyl esterified zinc complex and characterised as (20-hydroxyprotoporphyrinato dimethyl ester)zinc(II) by NOESY, visible absorption and ESI-MS; the structure sheds light on the mechanism of action of endoperoxide antimalarials.

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页码：2163 / 2166

页数：4

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