Macrocyclization of terminal bis-allylic chlorides via an intramolecular gem-dialkylation of malononitrile or methyl cyanoacetate

被引：2

作者：

Chantigny, Y ^{[1
]}

Toró, A ^{[1
]}

Lemelin, CA ^{[1
]}

Deslongchamps, P ^{[1
]}

机构：

[1] Univ Sherbrooke, Inst Pharmacol Sherbrooke, Dept Chim, Synth Organ Lab, Sherbrooke, PQ J1H 5N4, Canada

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 43期

关键词：

alkylation; coupling reagents; cyano compounds; macrocycles;

D O I：

10.1016/S0040-4039(98)01722-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A procedure is described for the stereospecific synthesis of 13-membered trienic macrocycles from suitable acyclic bis-allylic chlorides via an intramolecular gem-dialkylation of malononitrile or methyl cyanoacetate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7839 / 7840

页数：2

共 4 条

[1] CYCLIZATION OF YLIDENEMALONONITRILES .9. REARRANGEMENT OF 2-CYANO-3-(1-METHYLCYCLOPENTYL)INDENONE TO 4A-METHYL-9-OXO-10-CYANO-1,2,3,4,4A,9-HEXAHYDROPHENANTHRENE [J].