A glucose sensing contact lens: A non-invasive technique for continuous physiological glucose monitoring

被引:88
作者
Badugu, R
Lakowicz, JR [1 ]
Geddes, CD
机构
[1] Univ Maryland, Sch Med, Ctr Med Biotechnol, Dept Biochem & Mol Biol,Ctr Fluorescence Spect, Baltimore, MD 21201 USA
[2] Univ Maryland, Inst Biotechnol, Inst Fluorescence, Baltimore, MD 21201 USA
[3] Univ Maryland, Inst Biotechnol, Ctr Fluorescence Spect, Baltimore, MD 21201 USA
关键词
glucose monitoring; non-invasive; continuous monitoring; contact lens;
D O I
10.1023/A:1026103804104
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We have developed a range of glucose sensing contact lenses, using a daily, disposable contact lens embedded with newly developed boronic acid containing fluorophores. Our findings show that our approach may be suitable for the continuous monitoring of tear glucose levels in the range 50 1000 muM, which typically track blood glucose levels, which are approximate to5-10 fold higher. Our non-invasive approach may well offer an alternative solution to current invasive glucose monitoring techniques for diabetes, such as "finger pricking."
引用
收藏
页码:371 / 374
页数:4
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