Nanonization strategies for poorly water-soluble drugs

被引：494

作者：

Chen, Huabing ^{[1
]}

Khemtong, Chalermchai ^{[1
]}

Yang, Xiangliang ^{[2
]}

Chang, Xueling ^{[3
]}

Gao, Jinming ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

[2] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China

[3] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2011年 / 16卷 / 7-8期

关键词：

DELIVERY-SYSTEMS; POLYMERIC MICELLES; NANOEMULSION FORMULATIONS; CELECOXIB NANOEMULSION; TUMOR-CELLS; PHASE-I; NANOCRYSTALS; CANCER; SOLUBILITY; PACLITAXEL;

D O I：

10.1016/j.drudis.2010.02.009

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor (R) EL). In this review, several major nanonization techniques that seek to overcome these limitations for drug solubilization are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric micelles are reviewed. Finally, perspectives on existing challenges and future opportunities are highlighted.

引用

收藏

页码：354 / 360

页数：7

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