Interactions between prion protein isoforms: the kiss of death?

被引：114

作者：

Caughey, B ^{[1
]}

机构：

[1] NIH, Persistent Viral Dis Lab, Rocky Mt Labs, NIAID, Hamilton, MT 59840 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(01)01792-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Direct interactions between the normal and aberrant forms of prion protein appear to be crucial in the transmission and pathogenesis of transmissible spongiform encephalopathies (TSEs) or prion diseases. Recent studies of such interactions in vitro have provided mechanistic insight into how TSE-associated prion protein might promote its own propagation in a man ner that is specific enough to account, at least in part, for TSE strains and species barriers.

引用

页码：235 / 242

页数：8

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