BamTools: a C++ API and toolkit for analyzing and managing BAM files

被引：628

作者：

Barnett, Derek W. ^{[1
]}

Garrison, Erik K. ^{[1
]}

Quinlan, Aaron R. ^{[2
,3
]}

Stroemberg, Michael P. ^{[4
]}

Marth, Gabor T. ^{[1
]}

机构：

[1] Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA

[2] Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA

[3] Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

[4] Illumina Inc, San Diego, CA 92121 USA

来源：

BIOINFORMATICS | 2011年 / 27卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/bioinformatics/btr174

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Analysis of genomic sequencing data requires efficient, easy-to-use access to alignment results and flexible data management tools (e.g. filtering, merging, sorting, etc.). However, the enormous amount of data produced by current sequencing technologies is typically stored in compressed, binary formats that are not easily handled by the text-based parsers commonly used in bioinformatics research. Results: We introduce a software suite for programmers and end users that facilitates research analysis and data management using BAM files. BamTools provides both the first C++ API publicly available for BAM file support as well as a command-line toolkit.

引用

页码：1691 / 1692

页数：2

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