Characteristics of the mouse genomic histamine H1 receptor gene

被引：25

作者：

Inoue, I

Taniuchi, I

Kitamura, D

Jenkins, NA

Gilbert, DJ

Copeland, NG

Watanabe, T

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT MOL IMMUNOL,HIGASHI KU,FUKUOKA 812,JAPAN

[2] NCI,FREDERICK CANC RES & DEV CTR,MAMMALIAN GENET LAB,ABL BASIC RES PROGRAM,FREDERICK,MD 21702

来源：

GENOMICS | 1996年 / 36卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0441

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein-coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine H1 receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p. (C) 1996 Academic Press, Inc.

引用

页码：178 / 181

页数：4

共 12 条

[1] CDNA CLONING, EXPRESSION, MUTAGENESIS, INTRACELLULAR-LOCALIZATION, AND GENE CHROMOSOMAL ASSIGNMENT OF MOUSE 5-LIPOXYGENASE [J].