A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimer's disease

被引：95

作者：

Ramachandran, G

Marder, K

Tang, M

Schofield, PW

Chun, MR

Devanand, DP

Stern, Y

Mayeux, R

机构：

[1] COLUMBIA UNIV,GERTRUDE H SERGIEVSKY CTR,NEW YORK,NY 10032

[2] COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL,NEW YORK,NY 10032

[3] COLUMBIA UNIV COLL PHYS & SURG,CTR ALZHEIMERS DIS RES CITY NEW YORK,NEW YORK,NY 10032

[4] COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

[5] COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT,NEW YORK,NY 10032

来源：

NEUROLOGY | 1996年 / 47卷 / 01期

关键词：

D O I：

10.1212/WNL.47.1.256

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated the frequency of depression and psychosis in 46 patients with AD and 135 control subjects with the apolipoprotein (APO) E3/3 or E3/4 genotype. Patients with AD and the APOE3/4 genotype had a more than threefold increase in the signs of depression and psychosis when compared with either patients with the APOE3/3 genotype or to control subjects. Our preliminary study suggests that the phenotype of AD associated with the epsilon 4 allele is more likely to include psychiatric manifestations.

引用

页码：256 / 259

页数：4

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[3]

LOPEZALBEROLA R, 1994, NEUROLOGY, V44, pA207

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