Plexin A is a neuronal semaphorin receptor that controls axon guidance

被引:383
作者
Winberg, ML
Noordermeer, JN
Tamagnone, L
Comoglio, PM
Spriggs, MK
Tessier-Lavigne, M
Goodman, CS [1 ]
机构
[1] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[2] Univ Turin, Sch Med, Inst Canc Res, Dept Mol Oncol, I-10060 Turin, Italy
[3] Immunex Corp, Dept Mol Biol, Seattle, WA 98101 USA
[4] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Anat, San Francisco, CA 94143 USA
[5] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0092-8674(00)81715-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Semaphorins comprise a large family of secreted and transmembrane proteins, some of which function as repellents during axon guidance. Semaphorins fall into seven subclasses. Neuropilins are neuronal receptors for class III Semaphorins. In the immune system, VESPR, a member of the Plexin family, is a receptor for a viral-encoded Semaphorin. Here, we identify two Drosophila Plexins, both of which are expressed in the developing nervous system. We present evidence that Plexin A is a neuronal receptor for class I Semaphorins (Sema 1a and Sema 1b) and show that Plexin A controls motor and CNS axon guidance. Plexins, which themselves contain complete Semaphorin domains, may be both the ancestors of classical Semaphorins and binding partners for Semaphorins.
引用
收藏
页码:903 / 916
页数:14
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