共 100 条
Beta cell mass in diabetes: a realistic therapeutic target?
被引:119
作者:

Meier, J. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Ruhr Univ Bochum, Dept Med 1, St Josef Hosp, D-44791 Bochum, Germany Ruhr Univ Bochum, Dept Med 1, St Josef Hosp, D-44791 Bochum, Germany
机构:
[1] Ruhr Univ Bochum, Dept Med 1, St Josef Hosp, D-44791 Bochum, Germany
关键词:
apoptosis;
beta cell imaging;
beta cell turnover;
beta cell rest;
GLP-1;
proliferation;
sulfonylureas;
type;
1;
diabetes;
2;
D O I:
10.1007/s00125-008-0936-9
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement of beta cell function is therefore the logical long-term solution to therapy. This review sets out to describe the defects in beta cell mass and function in both forms of diabetes, summarises current understanding of the underlying causes of beta cell death, and the methodological limitations of determining beta cell mass in vivo. Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered.
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页码:703 / 713
页数:11
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