Beta cell mass in diabetes: a realistic therapeutic target?

被引:119
作者
Meier, J. J. [1 ]
机构
[1] Ruhr Univ Bochum, Dept Med 1, St Josef Hosp, D-44791 Bochum, Germany
关键词
apoptosis; beta cell imaging; beta cell turnover; beta cell rest; GLP-1; proliferation; sulfonylureas; type; 1; diabetes; 2;
D O I
10.1007/s00125-008-0936-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement of beta cell function is therefore the logical long-term solution to therapy. This review sets out to describe the defects in beta cell mass and function in both forms of diabetes, summarises current understanding of the underlying causes of beta cell death, and the methodological limitations of determining beta cell mass in vivo. Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered.
引用
收藏
页码:703 / 713
页数:11
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共 100 条
[1]   Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes [J].
Ahrén, B ;
Gomis, R ;
Standl, E ;
Mills, D ;
Schweizer, A .
DIABETES CARE, 2004, 27 (12) :2874-2880
[2]   Effect of exenatide on β cell function after islet transplantation in type 1 diabetes [J].
Al Ghofaili, Khalid ;
Fung, Michelle ;
Ao, Ziliang ;
Meloche, Mark ;
Shapiro, R. Jean ;
Warnock, Garth L. ;
Elahi, Darlush ;
Meneilly, Graydon S. ;
Thompson, David M. .
TRANSPLANTATION, 2007, 83 (01) :24-28
[3]   Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients [J].
Alvarsson, M ;
Sundkvist, G ;
Lager, I ;
Henricsson, M ;
Berntorp, K ;
Fernqvist-Forbes, E ;
Steen, L ;
Westermark, G ;
Westermark, P ;
Örn, T ;
Grill, V .
DIABETES CARE, 2003, 26 (08) :2231-2237
[4]   Diazoxide treatment at onset preserves residual insulin secretion in adults with autoimmune diabetes [J].
Bjork, E ;
Berne, C ;
Kampe, O ;
Wibell, L ;
Oskarsson, P ;
Karlsson, FA .
DIABETES, 1996, 45 (10) :1427-1430
[5]   EFFECTS OF A 48-H FAT INFUSION ON INSULIN-SECRETION AND GLUCOSE-UTILIZATION [J].
BODEN, G ;
CHEN, XH ;
ROSNER, J ;
BARTON, M .
DIABETES, 1995, 44 (10) :1239-1242
[6]   β-cell turnover -: Its assessment and implications [J].
Bonner-Weir, S .
DIABETES, 2001, 50 :S20-S24
[7]   PARTIAL PANCREATECTOMY IN THE RAT AND SUBSEQUENT DEFECT IN GLUCOSE-INDUCED INSULIN RELEASE [J].
BONNERWEIR, S ;
TRENT, DF ;
WEIR, GC .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 71 (06) :1544-1553
[8]   A 2ND PATHWAY FOR REGENERATION OF ADULT EXOCRINE AND ENDOCRINE PANCREAS - A POSSIBLE RECAPITULATION OF EMBRYONIC-DEVELOPMENT [J].
BONNERWEIR, S ;
BAXTER, LA ;
SCHUPPIN, GT ;
SMITH, FE .
DIABETES, 1993, 42 (12) :1715-1720
[9]   COMPENSATORY GROWTH OF PANCREATIC BETA-CELLS IN ADULT-RATS AFTER SHORT-TERM GLUCOSE-INFUSION [J].
BONNERWEIR, S ;
DEERY, D ;
LEAHY, JL ;
WEIR, GC .
DIABETES, 1989, 38 (01) :49-53
[10]   Proliferation and differentiation in the human fetal endocrine pancreas [J].
Bouwens, L ;
Lu, WG ;
DeKrijger, R .
DIABETOLOGIA, 1997, 40 (04) :398-404