Synthesis, hypotensive and antiarrhythmic activities of 3-alkyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)ureas or thioureas and their guanidine analogues

被引：44

作者：

Chalina, EG

Chakarova, L

机构：

[1] Med Univ Sofia, Fac Pharm, Dept Organ Chem, BG-1000 Sofia, Bulgaria

[2] Med Univ Sofia, Fac Pharm, Dept Pharmacol & Toxicol, BG-1000 Sofia, Bulgaria

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1998年 / 33卷 / 12期

关键词：

ureas; thioureas; guanidines; antiarrhythmic activity; hypotensive activity;

D O I：

10.1016/S0223-5234(99)80022-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new 3-alkyl-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro-3-naphthalenyl)ureas or thioureas and their guanidine analogues was synthesized from corresponding 3-amino-l,2,3,4-tetrahydronaphthalenes. Pharmacological tests showed that compounds 3-ethyl-1-(2-hydroxy-5,8-dimethoxy- 1,2,3,4-tetrahydro-3-naphthalenyl)urea 2a and 3-ethyl-l-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydro3-naphthalenyl)-3-morpholinomethylurea 3a possessed pronounced hypotensive and antiarrhythmic activities, as tested in anesthetized rats. (C) Elsevier, Paris.

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收藏

页码：975 / 983

页数：9

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