Ring constrained analogues of the orvinols: The furanomorphides.

被引：13

作者：

Husbands, SM ^{[1
]}

Breeden, SW ^{[1
]}

Grivas, K ^{[1
]}

Lewis, JW ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(99)00085-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of furanomorphides were synthesised as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the mu opioid receptor compared to the orvinols. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：831 / 834

页数：4

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