Meta-analysis identifies common variants associated with body mass index in east Asians

被引：297

作者：

Wen, Wanqing ^{[1
,2
,3
]}

Cho, Yoon-Shin ^{[4
,5
]}

Zheng, Wei ^{[1
,2
,3
]}

Dorajoo, Rajkumar ^{[6
,7
]}

Kato, Norihiro ^{[8
]}

Qi, Lu ^{[9
]}

Chen, Chien-Hsiun ^{[10
,11
]}

Delahanty, Ryan J. ^{[1
,2
,3
]}

Okada, Yukinori ^{[12
,13
]}

Tabara, Yasuharu ^{[14
]}

Gu, Dongfeng ^{[15
,16
,17
]}

Zhu, Dingliang ^{[18
,19
,20
,21
]}

Haiman, Christopher A. ^{[22
]}

Mo, Zengnan ^{[23
]}

Gao, Yu-Tang ^{[24
]}

Saw, Seang-Mei ^{[25
]}

Go, Min-Jin ^{[4
]}

Takeuchi, Fumihiko ^{[8
]}

Chang, Li-Ching ^{[10
]}

Kokubo, Yoshihiro ^{[26
]}

Liang, Jun ^{[27
]}

Hao, Mei ^{[28
]}

Le Marchand, Loic ^{[29
]}

Zhang, Yi ^{[18
,20
]}

Hu, Yanling ^{[30
]}

Wong, Tien-Yin ^{[31
,32
,33
]}

Long, Jirong ^{[1
,2
,3
]}

Han, Bok-Ghee ^{[4
]}

Kubo, Michiaki ^{[34
]}

Yamamoto, Ken ^{[35
]}

Su, Mei-Hsin ^{[10
]}

Miki, Tetsuro ^{[36
]}

Henderson, Brian E. ^{[22
]}

Song, Huaidong ^{[37
]}

Tan, Aihua ^{[38
]}

He, Jiang ^{[28
]}

Ng, Daniel P-K ^{[25
]}

Cai, Qiuyin ^{[1
,2
,3
]}

Tsunoda, Tatsuhiko ^{[39
]}

Tsai, Fuu-Jen ^{[11
]}

Iwai, Naoharu ^{[40
]}

Chen, Gary K. ^{[22
]}

Shi, Jiajun ^{[1
,2
,3
]}

Xu, Jianfeng ^{[41
]}

Sim, Xueling ^{[42
]}

Xiang, Yong-Bing ^{[24
]}

Maeda, Shiro ^{[43
]}

Ong, Rick T. H. ^{[6
,44
]}

Li, Chun ^{[45
]}

Nakamura, Yusuke ^{[46
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Div Epidemiol, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA

[4] Natl Inst Hlth, Ctr Genome Sci, Cheongwon Gun, South Korea

[5] Hallym Univ, Dept Biomed Sci, Chunchon, South Korea

[6] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore

[7] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Genom Common Dis, Hammersmith Hosp, London, England

[8] Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan

[9] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[10] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[11] China Med Univ, Sch Chinese Med, Taichung, Taiwan

[12] RIKEN, Lab Stat Anal, CGM, Yokohama, Kanagawa, Japan

[13] Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan

[14] Ehime Univ, Grad Sch Med, Dept Basic Med Res & Educ, Toon, Japan

[15] Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100730, Peoples R China

[16] Chinese Acad Med Sci, Fuwai Hosp, Beijing 100730, Peoples R China

[17] Peking Union Med Coll, Beijing 100021, Peoples R China

[18] Shanghai Jiao Tong Univ, State Key Lab Med Genom, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China

[19] Shanghai Jiao Tong Univ, Shanghai Inst Hypertens, Ruijin Hosp, Sch Med, Shanghai 200030, Peoples R China

[20] Sino French Res Ctr Life Sci & Genom, Shanghai, Peoples R China

[21] Shanghai Key Lab Vasc Biol, Shanghai, Peoples R China

[22] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA 90033 USA

[23] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning, Peoples R China

[24] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[25] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore

[26] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka, Japan

[27] Southeast Univ, Affiliated Hosp, Cent Hosp Xuzhou, Dept Endocrinol, Xuzhou, Peoples R China

[28] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA

[29] Univ Hawaii, Canc Res Ctr, Epidemiol Program, Honolulu, HI 96813 USA

[30] Guangxi Med Univ, Med Sci Res Ctr, Nanning, Peoples R China

[31] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore

[32] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 117595, Singapore

[33] Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic, Australia

[34] RIKEN, CGM, Lab Genotyping Dev, Yokohama, Kanagawa, Japan

[35] Kyushu Univ, Med Inst Bioregulat, Div Genome Anal, Fukuoka 812, Japan

[36] Ehime Univ, Grad Sch Med, Dept Geriatr Med, Toon, Japan

[37] Shanghai Jiao Tong Univ, State Key Lab Med Genom, Mol Med Ctr, Shanghai Inst Endocrinol,Ruijin Hosp, Shanghai 200030, Peoples R China

[38] Guangxi Med Univ, Affiliated Hosp 1, Ctr Metab Dis & Diabet, Nanning, Peoples R China

[39] RIKEN, CGM, Lab Med Informat, Yokohama, Kanagawa, Japan

[40] Natl Cerebral & Cardiovasc Ctr, Dept Genom Med, Suita, Osaka, Japan

[41] Wake Forest Univ, Bowman Gray Sch Med, Ctr Canc Genom, Winston Salem, NC USA

[42] Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore

[43] RIKEN, CGM, Lab Endocrinol & Metab, Yokohama, Kanagawa, Japan

[44] Natl Univ Singapore, Grad Sch Integrat Sci & Engn, Singapore 117548, Singapore

[45] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37212 USA

[46] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Mol Med, Tokyo, Japan

[47] Shanghai Municipal Ctr Dis Control & Prevent, Shanghai, Peoples R China

[48] Aichi Gakuin Univ, Sch Dent, Dept Genome Sci, Nagoya, Aichi 464, Japan

[49] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

[50] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 03期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; ADULT OBESITY; RISK LOCI; FTO GENE; POPULATIONS; SNP; DATABASE; TRAITS; CDKAL1; MC4R;

D O I：

10.1038/ng.1087

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 x 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 x 10(-7). Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.

引用

页码：307 / U112

页数：7

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