A2E, a byproduct of the visual cycle

被引：225

作者：

Sparrow, JR

Fishkin, N

Zhou, JL

Cai, BL

Jang, YP

Krane, S

Itagaki, Y

Nakanishi, K

机构：

[1] Columbia Univ, Dept Ophthalmol, New York, NY 10032 USA

[2] Columbia Univ, Dept Chem, New York, NY 10032 USA

来源：

VISION RESEARCH | 2003年 / 43卷 / 28期

关键词：

aging; atrophy; lipofuscin; retinal pigment epithelium; retinoids;

D O I：

10.1016/S0042-6989(03)00475-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributable to its amphiphilic structure and its photoreactivity, is consistent with evidence of an association between atrophic age-related macular degeneration (AMD) and excessive lipofuscin accumulation. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2983 / 2990

页数：8

共 76 条

[1] The effect of lipid environment and retinoids on the ATPase activity of ABCR, the photoreceptor ABC transporter responsible for Stargardt macular dystrophy [J].