Histopathological subtypes and prognosis of gastric cancer are correlated with the expression of mucin-associated sialylated antigens:: Sialosyl-Lewisa, sialosyl-Lewisx and sialosyl-Tn

被引：60

作者：

Baldus, SE

Zirbes, TK

Mönig, SP

Engel, S

Monaca, E

Rafiqpoor, K

Hanisch, FG

Hanski, C

Thiele, J

Pichlmaier, H

Dienes, HP

机构：

[1] Univ Cologne, Inst Pathol, D-50924 Cologne, Germany

[2] Univ Cologne, Dept Surg, D-50924 Cologne, Germany

[3] Univ Cologne, Inst Biochem, D-50924 Cologne, Germany

[4] Free Univ Berlin, Klinikum Steglitz, Dept Gastroenterol, D-1000 Berlin, Germany

来源：

TUMOR BIOLOGY | 1998年 / 19卷 / 06期

关键词：

gastric cancer; immunohistochemistry; monoclonal antibodies; sialylated antigens;

D O I：

10.1159/000030036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of three sialylated mucin-associated antigens - sialosyl-Lewis(a) (SLEA), sialosyl-Lewis(x) (SLEX) and sialosyl-Tn (STN)- and their correlation with the TNM stage, histopathological growth pattern and prognosis was investigated in a series of 127 gastric carcinomas. Various classification systems (pTNM, WHO and Lauren) did not display any correlation with an expression of the sialomucin antigens under study. SLEA reactivity was strongly associated with an unfavorable outcome of the total population, whereas SLEX and STN did not exert such an impact. However, in the subgroups of pTNM stage I as well as pNO patients, SLEA and SLEX reactivity of the tumors was associated with a worse prognosis. In the subgroup of diffuse-type cancers as defined according to Lauren's classification, the expression of all three antigens indicated a worsening of the prognosis.

引用

页码：445 / 453

页数：9

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