Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community-acquired pneumonia (CAP), as presented with biologic half-life times

被引：41

作者：

Takata, Saori ^{[1
]}

Wada, Hiroo ^{[1
]}

Tamura, Masaki ^{[1
]}

Koide, Takashi ^{[1
]}

Higaki, Manabu ^{[1
]}

Mikura, Shin-ichiro ^{[1
]}

Yasutake, Tetsuo ^{[1
]}

Hirao, Susumu ^{[1
]}

Nakamura, Masuo ^{[1
]}

Honda, Koujiro ^{[1
]}

Nagatomo, Tomoko ^{[1
]}

Tanaka, Yasutaka ^{[1
]}

Sohara, Erei ^{[1
]}

Watanabe, Masato ^{[1
]}

Yokoyama, Takuma ^{[1
]}

Saraya, Takeshi ^{[1
]}

Kurai, Daisuke ^{[1
]}

Ishii, Haruyuki ^{[1
]}

Goto, Hajime ^{[1
]}

机构：

[1] Kyorin Univ, Dept Resp Med, Sch Med, Tokyo 1818611, Japan

来源：

BIOMARKERS | 2011年 / 16卷 / 06期

关键词：

Community-acquired pneumonia (CAP); serum amyloid A (SAA); C-reactive protein (CRP); biologic half-life time; kinetics; PLASMA-CLEARANCE; MANAGEMENT; EXPRESSION;

D O I：

10.3109/1354750X.2011.607189

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: In management of community-acquired pneumonia (CAP), excellent biomarkers for inflammation would be helpful in our practice. Objectives: Kinetics of c-reactive protein (CRP) and serum amyloid A (SAA) was characterized, using their biologic half-life times. Materials and methods: Time course of CRP and SAA levels in the successfully treated 36 CAP patients were investigated and their half-life times were determined and compared. Results & Discussions: SAA and CRP declined in an exponential mean and the biologic half-life times of SAA levels was 34.9 +/- 28.7 h, significantly shorter than that of CRP, 46.4 +/- 21.7 h (p = 0.0014). Conclusion: The kinetic evidence, presented as biologic half-life times of CRP and SAA, helps us make a clinical assessment of CAP patients.

引用

页码：530 / 535

页数：6

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