The value of HDL genetics

被引:59
作者
Holleboom, Adriaan G. [1 ]
Vergeer, Menno [1 ]
Hovingh, G. Kees [1 ]
Kastelein, John J. P. [1 ]
Kuivenhoven, Jan Albert [1 ]
机构
[1] Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands
关键词
genetics; genome-wide analysis; high-density lipoprotein cholesterol;
D O I
10.1097/MOL.0b013e328306a043
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Purpose of review To review studies on hereditary disorders of HDL metabolism and studies on HDL genetics in mice, which have both provided valuable insight into the pathways of this intriguing lipoprotein and revealed targets to raise HDL cholesterol to reduce atherosclerosis. Recent findings To date, as many as 11 genes are considered key players in the synthesis, maturation, conversion and/or catabolism of HDL. Five of these genes have been identified in humans, APOA1, LCAT, ABCA1, LIPC and CETP, whereas the other six genes have been identified in mice, SCARB1, ABCG1, ATPB5, PLTP, LIPG and APOM. Genetic association studies are as yet the best line of evidence of the roles of the 'murine genes' in human HDL pathways. In addition to recent genetic association studies, a third section describes exciting news on six newly proposed HDL genes VNN1, GALNT2, MMABIMVK, CT alpha, BMP-1 and SIRT1. Summary This review provides a summary of the current literature on the genetics of HDL. New information from this research area may assist us in obtaining a better understanding of HDL biology and identifying novel pharmacological targets.
引用
收藏
页码:385 / 394
页数:10
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