Relationship between metabolic enzyme polymorphism and colorectal cancer

被引：77

作者：

Chen, Kun ^{[1
]}

Jiang, Qin-Ting ^{[1
]}

He, Han-Qing ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Epidemiol & Hlth Stat, Hangzhou 310031, Zhejiang, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Colorectal cancer; Glutathione S-transferase T1; N-acetyltransferase; Polymorphism;

D O I：

10.3748/wjg.v11.i3.331

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To clarify the influence of genetic polymorphisms on colorectal cancer. METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data. RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05). CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：331 / 335

页数：5

共 31 条

[1]

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