Activation-dependent induction of Blimp-1

被引：74

作者：

Calame, Kathryn ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 03期

关键词：

D O I：

10.1016/j.coi.2008.04.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B lymphocyte induced maturation protein-1 (Blimp-1) mRNA is induced upon antigen-dependent activation of both T and B lymphocytes, in spite of the fact that it plays very different roles in the two lineages. B cells have at least four different mechanisms to repress Blimp-1 and repression is relieved before induction. Only one repressor, Bcl-6, is known in T cells. Activators must also be present to induce Blimp-1 in both T and B cells. Cytokines IL-21, IL-1.0, and IL-6, activating STAT3, are crucial in B cells along with toll-like receptor (TLR) signals, whereas IL-2 is crucial in T cells. AP-1, NF-kappa B, and IRF4 also activate Blimp-1.

引用

页码：259 / 264

页数：6

共 57 条

[1] Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo [J].

Angelin-Duclos, C ;

Cattoretti, G ;

Lin, KI ;

Calame, K .

JOURNAL OF IMMUNOLOGY, 2000, 165 (10) :5462-5471

[2] IL-2 receptor β-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells [J].

Burchill, Matthew A. ;

Yang, Jianying ;

Vogtenhuber, Christine ;

Blazar, Bruce R. ;

Farrar, Michael A. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (01) :280-290

[3] BCL-6 PROTEIN IS EXPRESSED IN GERMINAL-CENTER B-CELLS [J].

CATTORETTI, G ;

CHANG, CC ;

CECHOVA, K ;

ZHANG, JD ;

YE, BH ;

FALINI, B ;

LOUIE, DC ;

OFFIT, K ;

CHAGANTI, RSK ;

DALLAFAVERA, R .

BLOOD, 1995, 86 (01) :45-53

[4] Pax5: the guardian of B cell identity and function [J].

Cobaleda, Cesar ;

Schebesta, Alexandra ;

Delogu, Alessio ;

Busslinger, Meinrad .

NATURE IMMUNOLOGY, 2007, 8 (05) :463-470

[5] The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral [J].

de Gorter, David J. J. ;

Vos, Johanna C. M. ;

Pals, Steven T. ;

Spaargaren, Marcel .

JOURNAL OF IMMUNOLOGY, 2007, 178 (03) :1405-1414

[6] Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells [J].

Delogu, A ;

Schebesta, A ;

Sun, Q ;

Aschenbrenner, K ;

Perlot, T ;

Busslinger, M .

IMMUNITY, 2006, 24 (03) :269-281

[7] Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells [J].

Fornek, JL ;

Tygrett, LT ;

Waldschmidt, TJ ;

Poli, V ;

Rickert, RC ;

Kansas, GS .

BLOOD, 2006, 107 (03) :1085-1091

[8] MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation [J].

Fujita, N ;

Jaye, DL ;

Geigerman, C ;

Akyildiz, A ;

Mooney, MR ;

Boss, JM ;

Wade, PA .

CELL, 2004, 119 (01) :75-86

[9] Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function [J].

Fuxa, Martin ;

Busslinger, Meinrad .

JOURNAL OF IMMUNOLOGY, 2007, 178 (05) :3031-3037

[10] Cytokine-dependent blimp-1 expression in activated T cells inhibits IL-2 production [J].

Gong, Dapeng ;

Malek, Thomas R. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (01) :242-252

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