Optimized atomic radii for protein continuum electrostatics solvation forces

被引:92
作者
Nina, M [1 ]
Im, W [1 ]
Roux, B [1 ]
机构
[1] Univ Montreal, Dept Phys & chem, Montreal, PQ H3C 3J7, Canada
关键词
analytic continuum electrostatic solvation forces; finite-difference Poisson-Botzmann (FDPB) equation; solute-solvent dielectric boundary; optimized radii; amino acids;
D O I
10.1016/S0301-4622(98)00236-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recently, we presented a Green's function approach for the calculation of analytic continuum electrostatic solvation forces based on numerical solutions of the finite-difference Poisson-Botzmann (FDPB) equation [Im et al., Comp. Phys. Comm. 111(1998) 59]. In this treatment the analytic forces were explicitly defined as the first derivative of the FDPB continuum electrostatic free energy with respect to the coordinates of the solute atoms. A smooth intermediate region for the solute-solvent dielectric boundary needed to be introduced to avoid abrupt discontinuous variations in the solvation free energy and forces as a function of the atomic positions. In the present paper we extend the set of optimized radii, which was previously parametrized from molecular dynamics free energy simulations of the 20 standard amino acids with explicit solvent molecules [Nina et al., J. Phys. Chem. 101 (1997) 5239], to yield accurate solvation free energy by taking the influence of the smoothed dielectric region into account. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:89 / 96
页数:8
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