Chiral Bronsted acid catalyzed asymmetric Baeyer-Villiger reaction of 3-substituted cyclobutanones by using aqueous H2O2

被引：187

作者：

Xu, Senmiao ^{[1
]}

Wang, Zheng ^{[1
]}

Zhang, Xue

Zhang, Xumu

Ding, Kuiling ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 15期

关键词：

asymmetric catalysis; cyclobutanones; hydrogen peroxide; lactones; oxidations;

D O I：

10.1002/anie.200705932

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A catalytic amount of a chiral Brønsted acid with aqueous H2O2 as the oxidant is sufficient for the enantioselective Baeyer-Villiger oxidation of 3-substituted cyclobutanones to give the corresponding γ-lactones in excellent yields and up to 93% ee. The method employs benign aqueous H2O2 instead of stoichiometric amounts of a dangerous peracid. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2840 / 2843

页数：4

共 81 条

[1] Enantioselective Mannich-type reaction catalyzed by a chiral Bronsted acid [J].