Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity

被引:137
作者
Serretti, A [1 ]
Zanardi, R [1 ]
Rossini, D [1 ]
Cusin, C [1 ]
Lilli, R [1 ]
Smeraldi, E [1 ]
机构
[1] Univ Vita Salute San Raffaele, San Raffaele Inst, Dept Psychiat, Milan, Italy
关键词
tryptophan hydroxylase; serotonin transporter; pindolol; fluvoxamine; mood disorders; antidepressant treatment;
D O I
10.1038/sj.mp.4000876
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aim of the present study was to test a possible effect of the A218C tryptophan hydroxylase (TPH) gene variant on the antidepressant activity of fluvoxamine in a sample of major and bipolar depressives, with or without psychotic features. Two hundred and seventeen inpatients were treated with fluvoxamine 300 mg and either placebo or pindolol in a double blind design for 6 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression. TPH allelic variants were determined in each subject by using a PCR-based technique. No significant finding was observed in the overall sample as well as in the pindolol group, while TPH*A/A was associated with a slower response to fluvoxamine treatment in subjects not taking pindolol (P = 0.001). This effect was independent from the previously reported influence of 5-HTTLPR polymorphism. If confirmed, these results may shed further light on the genetically determined component of the response to pharmacological treatments, thus helping the clinician to individualize each patient's therapy according to their genetic pattern.
引用
收藏
页码:586 / 592
页数:7
相关论文
共 67 条
[1]  
ABBAR M, 1995, ARCH GEN PSYCHIAT, V52, P846
[2]   SCALES FOR ASSESSMENT OF DIAGNOSIS AND SEVERITY OF MENTAL-DISORDERS - PREFACE [J].
BECH, P ;
MALT, UF ;
DENCKER, SJ ;
AHLFORS, UG ;
ELGEN, K ;
LEWANDER, T ;
LUNDELL, A ;
SIMPSON, GM ;
LINGJAERDE, O .
ACTA PSYCHIATRICA SCANDINAVICA, 1993, 87 :3-3
[3]   A COMPARISON BETWEEN DELUSIONAL AND NONDELUSIONAL DEPRESSIVES [J].
BELLINI, L ;
GATTI, F ;
GASPERINI, M ;
SMERALDI, E .
JOURNAL OF AFFECTIVE DISORDERS, 1992, 25 (02) :129-138
[4]   Association between the tryptophan hydroxylase gene and manic-depressive illness [J].
Bellivier, F ;
Leboyer, M ;
Courtet, P ;
Buresi, C ;
Beaufils, B ;
Samolyk, D ;
Allilaire, JF ;
Feingold, J ;
Mallet, J ;
Malafosse, A .
ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (01) :33-37
[5]  
Benedetti F, 1999, AM J PSYCHIAT, V156, P1450
[6]   Tryptophan hydroxylase polymorphisms in suicide victims [J].
Bennett, PJ ;
McMahon, WM ;
Watabe, J ;
Achilles, J ;
Bacon, M ;
Coon, H ;
Grey, T ;
Keller, T ;
Tate, D ;
Tcaciuc, I ;
Workman, J ;
Gray, D .
PSYCHIATRIC GENETICS, 2000, 10 (01) :13-17
[7]   Progress and pitfalls: bipolar molecular linkage studies [J].
Berrettini, W .
JOURNAL OF AFFECTIVE DISORDERS, 1998, 50 (2-3) :287-297
[8]   COMPLETE CODING SEQUENCE OF HUMAN TRYPTOPHAN-HYDROXYLASE [J].
BOULARAND, S ;
DARMON, MC ;
GANEM, Y ;
LAUNAY, JM ;
MALLET, J .
NUCLEIC ACIDS RESEARCH, 1990, 18 (14) :4257-4257
[9]  
Cohen J., 1998, Statistical Power Analysis for the Behavioral Sciences, V2nd
[10]  
COMINGS D, 1997, HDB PSYCHIAT GENETIC, P235