Central role of the P2Y12 receptor in platelet activation

被引：461

作者：

Dorsam, RT

Kunapuli, SP

机构：

[1] Temple Univ, Dept Physiol, Sch Med, Philadelphia, PA 19140 USA

[2] Temple Univ, Dept Pharmacol, Sch Med, Philadelphia, PA 19140 USA

[3] Temple Univ, Sol Sherry Thrombosis Res Ctr, Sch Med, Philadelphia, PA 19140 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 03期

关键词：

D O I：

10.1172/JCI200420986

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.

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收藏

页码：340 / 345

页数：6

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