Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons

被引：40

作者：

Arancio, O

LevRam, V

Tsien, RY

Kandel, ER

Hawkins, RD

机构：

[1] COLUMBIA UNIV,CTR NEUROBIOL & BEHAV,NEW YORK,NY 10027

[2] NEW YORK STATE PSYCHIAT INST & HOSP,NEW YORK,NY 10032

[3] HOWARD HUGHES MED INST,NEW YORK,NY 10032

[4] UNIV CALIF SAN DIEGO,DEPT PHARMACOL,LA JOLLA,CA 92093

[5] UNIV CALIF SAN DIEGO,HOWARD HUGHES MED INST,LA JOLLA,CA 92093

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1996年 / 90卷 / 5-6期

关键词：

long-term potentiation (LTP); nitric oxide; retrograde messenger; photolytic release;

D O I：

10.1016/S0928-4257(97)87907-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined long-term potentiation (LTP) at synapses between hippocampal neurons in dissociated cell culture following presynaptic, postsynaptic, or extracellular application of a nitric oxide (NO) scavenger, an inhibitor of NO synthase, and a membrane-impermeant NO donor that releases NO only upon photolysis with UV light. Our results indicate that NO is produced in the postsynaptic neuron, travels through the extracellular space, and acts directly in the presynaptic neuron to produce long-term potentiation, supporting the hypothesis that NO acts a retrograde messenger during LTP.

引用

页码：321 / 322

页数：2

共 14 条

[1] ACTIVITY-DEPENDENT LONG-TERM ENHANCEMENT OF TRANSMITTER RELEASE BY PRESYNAPTIC 3',5'-CYCLIC GMP IN CULTURED HIPPOCAMPAL-NEURONS [J].