Systemic concentrations of hormones during the development of follicular waves in mares and women: a comparative study

被引:113
作者
Ginther, OJ
Beg, MA
Gastal, EL
Gastal, MO
Baerwald, AR
Pierson, RA
机构
[1] Univ Wisconsin, Madison, WI 53706 USA
[2] Eutheria Fdn, Cross Plains, WI 53528 USA
[3] Univ Saskatchewan, Coll Med, Womens Hlth Imaging Res Lab, Dept Obstet Gynecol & Reprod Sci, Saskatoon, SK S7N 0W8, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1530/rep.1.00757
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Changes in systemic concentrations of FSH, LH, oestradiol and progesterone during the ovulatory follicular wave were compared between 30 mares and 30 women. Based on a previous study, the emergence of the future ovulatory follicle was defined as occurring at 13.0 mm in mares and 6.0 mm in women, and deviation in diameter between the two largest follicles was expected to begin at 22.7 mm in mares and 10.3 mm in women. Mean FSH concentrations were high in mares during the luteal phase, resulting from statistically identified FSH surges occurring in individuals on different days and in different numbers (mean, 1.5 +/- 0.2 surges/mare); the internadir interval was 3.9 +/- 0.3 days. In contrast, mean FSH in women was low during the luteal phase and increased to a prolonged elevation during the follicular phase. The prolonged elevation was apparent in each individual (internadir interval, 15.2 +/- 0.4 days). Changes in LH or oestradiol concentrations encompassing deviation were not detected in mares, but both hormones increased slightly but significantly between emergence and deviation in women. The hypothesis that a greater number of growing follicles causes a greater predeviation decrease in FSH was supported for mares (r, - 0.39; P < 0.04), but a similar negative correlation (r, - 0.36) was not significant in women. The hypothesis that the increase in oestradiol during the luteal phase in women was at least partly attributable to luteal-phase anovulatory follicular waves was not supported. Normalization of FSH concentrations to the day of emergence showed maximum value on the day of emergence with a significant increase and decrease on each side of emergence in both species. The day of expected deviation occurred 3 days after emergence during the decline in FSH in both species. These results indicated that the previously reported striking similarities in emergence and deviation between mares and women during the ovulatory follicular wave are associated with species similarities in the temporal relationships between follicle events and FSH concentration changes. Thus, mares may be useful research models for studying the role and mechanism of the action of FSH in emergence and deviation during the ovulatory follicular wave in women.
引用
收藏
页码:379 / 388
页数:10
相关论文
共 26 条
[1]   Form and function of the corpus luteum during the human menstrual cycle [J].
Baerwald, AR ;
Adams, GP ;
Pierson, RA .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2005, 25 (05) :498-507
[2]   Characterization of ovarian follicular wave dynamics in women [J].
Baerwald, AR ;
Adams, GP ;
Pierson, RA .
BIOLOGY OF REPRODUCTION, 2003, 69 (03) :1023-1031
[3]  
BAIRD DT, 1984, J REPROD FERTIL, V70, P615
[4]  
BAIRD DT, 1975, J REPROD FERTIL, V45, P611, DOI 10.1530/jrf.0.0450611
[5]   CIRCULATING CONCENTRATIONS OF IMMUNOREACTIVE INHIBIN AND FSH DURING THE ESTROUS-CYCLE OF MARES [J].
BERGFELT, DR ;
MANN, BG ;
SCHWARTZ, NB ;
GINTHER, OJ .
JOURNAL OF EQUINE VETERINARY SCIENCE, 1991, 11 (06) :319-322
[6]  
BRIANT C, 2000, THERIOGENOLOGY, P53
[7]   Interactions of follicular factors and season in the regulation of circulating concentrations of gonadotrophins in mares [J].
Donadeu, FX ;
Ginther, OJ .
REPRODUCTION, 2003, 125 (05) :743-750
[8]   Changes in concentrations of follicular fluid factors during follicle selection in mares [J].
Donadeu, FX ;
Ginther, OJ .
BIOLOGY OF REPRODUCTION, 2002, 66 (04) :1111-1118
[9]   Effect of number and diameter of follicles on plasma concentrations of inhibin and FSH in mares [J].
Donadeu, FX ;
Ginther, OJ .
REPRODUCTION, 2001, 121 (06) :897-903
[10]   Manipulation of human ovarian function: Physiological concepts and clinical consequences [J].
Fauser, BCJM ;
VanHeusden, AM .
ENDOCRINE REVIEWS, 1997, 18 (01) :71-106