No evidence of linkage between schizophrenia and D2 dopamine receptor gene locus in Italian pedigrees

被引：9

作者：

Grassi, E

Mortilla, M

Amaducci, L

Pallanti, S

Pazzagli, A

Galassi, F

Guarnieri, BM

Petruzzi, C

Bolino, F

Ortenzi, L

Nistico, R

DeCataldo, S

Rossi, A

Sorbi, S

机构：

[1] UNIV LAQUILA,OSPED COLLE MAGGIORE,DIPARTIMENTO PSICHIAT,I-67100 LAQUILA,ITALY

[2] ASSOC L PETRUZZI,PESCARA,ITALY

[3] UNITA SOCIOSANITARIA PENNE,PESCARA,ITALY

来源：

NEUROSCIENCE LETTERS | 1996年 / 206卷 / 2-3期

关键词：

linkage analysis; schizophrenia; bipolar disorders; D2 dopamine receptor; tyrosine hydroxylase; monoamino oxydase A;

D O I：

10.1016/S0304-3940(96)12463-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders. We have analyzed seven Italian families with schizophrenia and four families with bipolar disorders for a total of 68 individuals; 32 individuals were affected. Diagnoses were made using the structured clinical interview Schedule for Affective Disorders and Schizophrenia, Lifetime version (SADS-L). The results of our study provide no evidence of linkage between alleles at D2 dopamine receptor loci and schizophrenia or bipolar disorders. The markers TH gene and MAO-A gene give slightly positive or negative results suggesting the utility of further analysis on more informative families.

引用

页码：196 / 198

页数：3

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