A novel extracellular diterpenoid with antibacterial activity from the cyanobacterium Nostoc commune

被引：83

作者：

Jaki, B ^{[1
]}

Orjala, J ^{[1
]}

Sticher, O ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Dept Pharm, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 03期

关键词：

D O I：

10.1021/np980444x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A novel extracellular metabolite with an unprecedented diterpenoid skeleton, 8-[(5-carboxy-2-hydroxy)benzyl]-2-hydroxy-1,1,4a,7,8-pentamethyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydrophenanthrene has been isolated from the culture medium of the terrestrial cyanobacterium Nostoc commune Vaucher (EAWAG 122b) by means of bioguided isolation. The molecule was designated as noscomin. The structure was determined by spectroscopic methods, mainly NMR and mass spectrometry. Noscomin exhibited antibacterial activity against Bacillus cereus, Staphylococcus epidermidis, and Escherichia coli.

引用

页码：502 / 503

页数：2

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