Immunotherapy for Gastroesophageal Cancer

被引：51

作者：

Goode, Emily F. ^{[1
]}

Smyth, Elizabeth C. ^{[1
]}

机构：

[1] NHS Fdn Trust, Royal Marsden Hosp, London SW3 6JJ, England

来源：

JOURNAL OF CLINICAL MEDICINE | 2016年 / 5卷 / 10期

关键词：

anti-PD-1; anti-PD-L1; checkpoint inhibitor; ipilimumab; esophageal cancer; gastric cancer; immunotherapy; pembrolizumab; nivolumab; ADVANCED GASTRIC-CANCER; TUMOR-INFILTRATING LYMPHOCYTES; HELICOBACTER-PYLORI INFECTION; PHASE-II TRIAL; T-CELL THERAPY; MICROSATELLITE INSTABILITY; PD-1; BLOCKADE; OPEN-LABEL; PROGNOSTIC IMPLICATIONS; SUPPORTIVE CARE;

D O I：

10.3390/jcm5100084

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Survival for patients with advanced oesophageal and stomach cancer is poor; together these cancers are responsible for more than a million deaths per year globally. As chemotherapy and targeted therapies such as trastuzumab and ramucirumab result in modest improvements in survival but not long-term cure for such patients, development of alternative treatment approaches is warranted. Novel immunotherapy drugs such as checkpoint inhibitors have been paradigm changing in melanoma, non-small cell lung cancer and urothelial cancers. In this review, we assess the early evidence for efficacy of immunotherapy in patients with gastroesophageal cancer in addition to considering biomarkers associated with response to these treatments. Early results of Anti- Programmed Cell Death Protein-1 (anti-PD-1), anti-PD-L1 and anti-Cytotoxic T-lymphocyte assosciated protein-4 (anti-CTLA4) trials are examined, and we conclude with a discussion on the future direction for immunotherapy for gastroesophageal cancer patients.

引用

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