A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity

被引：273

作者：

Paulsen, O

Moser, EI

机构：

[1] Univ Oxford, Dept Pharmacol, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England

[2] Norwegian Univ Sci & Technol, Dept Psychol, N-7034 Trondheim, Norway

来源：

TRENDS IN NEUROSCIENCES | 1998年 / 21卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0166-2236(97)01205-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The current view of the role of GABAergic interneurones in cortical-network function has shifted from one of merely dampening neuronal activity to that of an active role in information processing. In this review, we explore a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditions for modifications of synaptic weights during hippocampus-dependent memory processes. We argue that knowledge of spatiotemporal activity-patterns in distinct classes of interneurone is essential to understanding the cellular mechanisms underlying learning and memory.

引用

收藏

页码：273 / 278

页数：6

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