Mutations of the BIK gene in human peripheral B-cell lymphomas

被引：45

作者：

Arena, V ^{[1
]}

Martini, M ^{[1
]}

Luongo, M ^{[1
]}

Capelli, A ^{[1
]}

Larocca, LM ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Ist Anat Patol, I-00168 Rome, Italy

来源：

GENES CHROMOSOMES & CANCER | 2003年 / 38卷 / 01期

关键词：

D O I：

10.1002/gcc.10245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BIK, a BH (Bcl2 homology domain)3-only protein, is a proapoptotic member of the BCL2 family. We performed single-strand conformational polymorphism and sequencing analysis of the entire coding region of the BIK gene (exons 2-5) in 71 B-cell lymphomas [27 follicular lymphomas (FLs), 13 marginal cell lymphomas (MZLs), 7 small lymphocytic lymphomas (SLLs), 6 mantle cell lymphomas (MCLs), 2 lymphoplasmacytic lymphomas, and 16 diffuse large B-cell lymphomas (DLBCLs)]. Missense BIK gene mutations were observed in 3 of 27 (11%) FLs, in 2 of 13 (15%) MZLs, and in I of 16 (6%) DLBCLs. Sequence alterations in intronic regions were observed in 4 of 27 (14.8%) FLs, in 7 of 13 (53%) MZLs, and in 3 of 16 (18%) DLBCLs. These data indicate that mutation of the BIK gene is a frequent feature of B-cell lymphomas. (C) 2003 Wiley-Liss, Inc.

引用

页码：91 / 96

页数：6

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