Synthesis and antimicrobial evaluation of some new thiazole, thiazolidinone and thiazoline derivatives starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde

被引：231

作者：

Bondock, Samir ^{[1
]}

Khalifa, Wesam ^{[1
]}

Fadda, Ahmed A. ^{[1
]}

机构：

[1] Univ Mansoura, Fac Sci, Dept Chem, Mansoura 35516, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 07期

关键词：

thiazoles; thiazolines; thiazolidinones; 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde; thiosemicarbazone; antimicrobial activity;

D O I：

10.1016/j.ejmech.2006.12.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The thiosemicarbazones (3 and 6) and N-arylidene cyanoacetohydrazide (12) were prepared and used as key intermediates for the synthesis of 4-thiazolidinones (4, 5, 7-9), thiazoles (10a,b and 11a-d) and thiazoline (13) derivatives. Treatment of 13 with a mixture of triethylorthoformate and acetic anhydride afforded thiazolo[5,4-d]pyrimidinone derivative (14). The newly synthesized compounds were characterized by IR, H-1 NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：948 / 954

页数：7

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