Subnets of scale-free networks are not scale-free: Sampling properties of networks

被引:349
作者
Stumpf, MPH
Wiuf, C
May, RM
机构
[1] Univ London Imperial Coll Sci Technol & Med, Ctr Bioinformat, London SW7 2AZ, England
[2] Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus, Denmark
[3] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
关键词
complex networks; protein interaction networks; random graphs; sampling theory;
D O I
10.1073/pnas.0501179102
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Most studies of networks have only looked at small subsets of the true network. Here, we discuss the sampling properties of a network's degree distribution under the most parsimonious sampling scheme. Only if the degree distributions of the network and randomly sampled subnets belong to the same family of probability distributions is it possible to extrapolate from subnet data to properties of the global network. We show that this condition is indeed satisfied for some important classes of networks, notably classical random graphs and exponential random graphs. For scale-free degree distributions, however, this is not the case. Thus, inferences about the scale-free nature of a network may have to be treated with some caution. The work presented here has important implications for the analysis of molecular networks as well as for graph theory and the theory of networks in general.
引用
收藏
页码:4221 / 4224
页数:4
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