Immune parameters affecting the efficacy of chemotherapeutic regimens

被引：557

作者：

Zitvogel, Laurence ^{[2
]}

Kepp, Oliver ^{[3
]}

Kroemer, Guido ^{[1
]}

机构：

[1] Univ Paris 05, Fac Med, Ctr Rech Cordeliers, INSERM,U872, F-75006 Paris, France

[2] Inst Gustave Roussy, INSERM, U1015, F-94805 Villejuif, France

[3] Inst Gustave Roussy, INSERM, U848, F-94805 Villejuif, France

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2011年 / 8卷 / 03期

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; REGULATORY T-CELLS; ADVANCED BREAST-CANCER; ACUTE MYELOID-LEUKEMIA; LONG-TERM SURVIVAL; PROGNOSTIC-FACTOR; CALRETICULIN EXPOSURE; COLORECTAL-CANCER; OVARIAN-CANCER; NEOADJUVANT CHEMOTHERAPY;

D O I：

10.1038/nrclinonc.2010.223

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The outcome of chemotherapy can be influenced by the host immune system at multiple levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or alternatively, by increasing their susceptibility to immune attack. In addition, chemotherapy can stimulate anticancer immune effectors either in a direct fashion or by subverting immunosuppressive mechanisms. Beyond cancer-cell-intrinsic factors that determine the cytotoxic or cytostatic response, as well as the potential immunogenicity of tumor cells, the functional state of the host immune system has a major prognostic and predictive impact on the fate of cancer patients treated with conventional or targeted chemotherapies. In this Review, we surmise that immune-relevant biomarkers may guide personalized therapeutic interventions including compensatory measures to restore or improve anticancer immune responses.

引用

页码：151 / 160

页数：10

共 89 条

[1] The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules:: implications for tumor immune escape [J].

Algarra, I ;

García-Lora, A ;

Cabrera, T ;

Ruiz-Cabello, F ;

Garrido, F .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2004, 53 (10) :904-910

[2] The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Criollo, Alfredo ;

Ortiz, Carla ;

Lidereau, Rosette ;

Mariette, Christophe ;

Chaput, Nathalie ;

Mira, Jean-Paul ;

Delaloge, Suzette ;

Andre, Fabrice ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

IMMUNOLOGICAL REVIEWS, 2007, 220 :47-59

[3] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[4] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[5]

Ashida A, 2006, INT J ONCOL, V28, P1345

[6] Correlation of NK T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFα in ascites from advanced ovarian cancer:: Association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapy [J].

Bamias, Aristotelis ;

Koutsoukou, Vasiliki ;

Terpos, Evangelos ;

Tsiatas, Marinos L. ;

Liakos, Christina ;

Tsitsilonis, Ourania ;

Rodolakis, Alexandros ;

Voulgaris, Zannis ;

Vlahos, G. ;

Papageorgiou, Theocharis ;

Papatheodoridis, G. ;

Archimandritis, A. ;

Antsaklis, A. ;

Dilnopoulos, M. A. .

GYNECOLOGIC ONCOLOGY, 2008, 108 (02) :421-427

[7] Cytokine loops driving senescence [J].

Bartek, Jiri ;

Hodny, Zdenek ;

Lukas, Jiri .

NATURE CELL BIOLOGY, 2008, 10 (08) :887-889

[8] SELECTIVE CHANGES IN THE IMMUNE PROFILE OF TUMOR-DRAINING LYMPH NODES AFTER DIFFERENT NEOADJUVANT CHEMORADIATION REGIMENS FOR LOCALLY ADVANCED CERVICAL CANCER [J].

Battaglia, Alessandra ;

Buzzonetti, Alexia ;

Martinelli, Enrica ;

Fanelli, Mara ;

Petrillo, Marco ;

Ferrandina, Gabriella ;

Scambia, Giovanni ;

Fattorossi, Andrea .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 76 (05) :1546-1553

[9] HMGB1 loves company [J].

Bianchi, Marco E. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (03) :573-576

[10] Selective BRAFV600E Inhibition Enhances T-Cell Recognition of Melanoma without Affecting Lymphocyte Function [J].

Boni, Andrea ;

Cogdill, Alexandria P. ;

Dang, Ping ;

Udayakumar, Durga ;

Njauw, Ching-Ni Jenny ;

Sloss, Callum M. ;

Ferrone, Cristina R. ;

Flaherty, Keith T. ;

Lawrence, Donald P. ;

Fisher, David E. ;

Tsao, Hensin ;

Wargo, Jennifer A. .

CANCER RESEARCH, 2010, 70 (13) :5213-5219

← 1 2 3 4 5 6 7 8 9 →