Endothelial cell marker expression in dysplastic lesions of the liver: an immunohistochemical study

被引:68
作者
Frachon, S
Gouysse, G
Dumortier, J
Couvelard, A
Nejjari, M
Mion, F
Berger, F
Paliard, P
Boillot, O
Scoazec, JY [1 ]
机构
[1] Hop Edouard Herriot, Serv Cent Anat & Cytol Pathol, F-68437 Lyon 03, France
[2] INSERM, U45, F-69008 Lyon, France
[3] Unite Transplantat Hepat, Lyon, France
[4] Hop Edouard Herriot, Fed Specialities Digest, Lyon, France
[5] Hop Bichat Claude Bernard, Serv Anat Pathol, F-75877 Paris 18, France
关键词
liver carcinogenesis; liver cell change; hepatocellular carcinoma; CD31; CD34; BNH9; angiogenesis; hepatic microcirculation; liver pathology;
D O I
10.1016/S0168-8278(01)00049-6
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Backgrounds/Aims: Hepatocellular carcinoma usually contains continuous capillary vessels lacking the differentiation markers specific for normal sinusoidal endothelial cells. We therefore aimed to search for alterations ill endothelial cell marker expression in precancerous liver lesions. Methods: Expression of the endothelial cell markers CD31, CD34 and BNH9 was analyzed in 138 dysplastic lesions from 40 cirrhotic patients (20 with and 20 without hepatocellular carcinoma). Results: No expression of the three endothelial cell markers was detected in cirrhotic nodules and in non dysplastic regenerative macronodules. The three markers were detected in 29.8 % of dysplastic lesions and 47% of hepatocellular carcinomas. At least one marker was detected in 75% of dysplastic lesions and 100% of hepatocellular carcinomas. The three markers were more frequently expressed in areas of small cell than of large cell change (34 vs 10%). No correlation was found with the grade of dysplasia, the occurrence of arterialization and the association with hepatocellular carcinoma. Conclusions: Alterations in the hepatic microcirculation comparable to those observed in hepatocellular carcinoma are present in a significant proportion of dysplastic lesions of the liver and may be indirect markers of the process of liver carcinogenesis. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码:850 / 857
页数:8
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