siRNAs targeting mouse myostatin

被引：6

作者：

Furalyov, V. A. ^{[1
]}

Kravchenko, I. V. ^{[1
]}

Khotchenkov, V. P. ^{[1
]}

Popov, V. O. ^{[1
]}

机构：

[1] Russian Acad Sci, Bach Inst Biochem, Moscow 119071, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 03期

关键词：

myostatin; siRNA; RNA interference; myoblasts;

D O I：

10.1134/S0006297908030164

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Eight different mouse myostatin small interfering RNA (siRNAs) were synthesized and tested. Five siRNAs showed a pronounced biological effect reducing myostatin mRNA content. For two of them, the myostatin mRNA level was reduced 3- and 4-fold, respectively. The obtained siRNAs can be used for study of biological effects of myostatin, both in vitro and in vivo.

引用

页码：342 / 345

页数：4

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