Protein kinase C in normal and pathologic myocardial states

被引：17

作者：

Cain, BS ^{[1
]}

Meldrum, DR ^{[1
]}

Harken, AH ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Surg, Denver, CO 80262 USA

来源：

JOURNAL OF SURGICAL RESEARCH | 1999年 / 81卷 / 02期

关键词：

TNF-alpha; translocation; adenosine; infarction; cardiac bypass; preconditioning; inflammation; sepsis; contraction; ischemia-reperfusion; ischemic preconditioning; isoforms; cPKC; nPKC; rat; human;

D O I：

10.1006/jsre.1998.5508

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Recent evidence has implicated protein kinase C (PKC) as an important mediator underlying multiple aspects of myocardial function. We and others have recently reported that PKC is involved in Ca2+-induced inotropy, in mediating myocardial preconditioning by diverse stimuli both in animals and humans, and in the signaling processes which lead to the production of proinflammatory mediators (cytokines). The purposes of this manuscript are ten explore the role of PKC in normal myocardial contraction, the role of PKC in mediating protection, the role of PKC: in inflammation, and the importance of inflammation regarding myocardial injury. (C) 1999 Academic Press.

引用

页码：249 / 259

页数：11

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