Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines

被引：53

作者：

Akihisa, T

Tokuda, H

Ichiishi, E

Mukainaka, T

Toriumi, M

Ukiya, M

Yasukawa, K

Nishino, H

机构：

[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 1018308, Japan

[2] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[3] Nihon Univ, Coll Pharm, Funabashi, Chiba 2748555, Japan

来源：

CANCER LETTERS | 2001年 / 173卷 / 01期

关键词：

Trichosanthes kirilowii; Cucurbitaceae; anti-tumor promoter; Epstein-Barr virus early antigens; multiflorane-type triterpenoids; structure-activity relationships; cytotoxicity;

D O I：

10.1016/S0304-3835(01)00689-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forty-nine multiflorane-type triterpenoids consisting of 11 compounds isolated from the seeds of Trichosanthes kirilowii (Cucurbitaceae) and 38 of their derivatives have been evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in Raji cells as a primary screening test for anti-tumor promoters. All of the compounds tested showed an inhibitory effect against EBV-EA activation, and among which 43 were revealed to possess remarkable activity with potencies either comparable to or stronger than that of glycyrrhetic acid, a known natural anti-tumor promoter. Their structure-activity relationship is discussed. Evaluation of the cytotoxic activity of karounidiol (27) against human cancer cell lines exhibited cytotoxicity especially against a human renal cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：9 / 14

页数：6

共 13 条

[1] 7-oxodihydrokarounidiol-3-benzoate and other triterpenes from the seeds of cucurbitaceae [J].