Immune response induction and new effector mechanisms possibly involved in protection conferred by the Cuban anti-meningococcal BC vaccine

被引：40

作者：

Perez, O ^{[1
]}

Lastre, M ^{[1
]}

Lapinet, J ^{[1
]}

Bracho, G ^{[1
]}

Diaz, M ^{[1
]}

Zayas, C ^{[1
]}

Taboada, C ^{[1
]}

Sierra, G ^{[1
]}

机构：

[1] Finlay Inst, Dept Basic & Clin Immunol, Havana, Cuba

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 07期

关键词：

D O I：

10.1128/IAI.69.7.4502-4508.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

This report explores the participation of some afferent mechanisms in the immune response induced by the Cuban anti-meningococcal vaccine VA-MENGOC-BC, The induction of delayed-type hypersensitivity in nursing babies and lymphocyte proliferation after immunization is demonstrated. The presence of gamma interferon IFN-gamma and interleukin-2 (IL-2) mRNAs but absence of IL-4, IL-5, and IL-10 mRNAs were observed in peripheral blood mononuclear cells from immunized subjects after in vitro challenge with outer membrane vesicles. In addition, some effector functions were also explored. The presence of opsonic activity was demonstrated in sera from vaccinees, The role of neutrophils as essential effector cells was shown. In conclusion, we have shown that, at least in the Cuban adult population, VA-MENGOC-BC induces mechanisms with a T-helper 1 pattern in the afferent and effector branches of the immune response.

引用

页码：4502 / 4508

页数：7

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