Polymorphisms within 5′ end of the Neuregulin 1 gene are genetically associated with schizophrenia in the Chinese population

被引:82
作者
Tang, JX
Chen, WY
He, G
Zhou, J
Gu, NF
Feng, GY
He, L
机构
[1] Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China
[2] Chinese Acad Sci, Inst Nutr Sci, Shanghai, Peoples R China
[3] Shanghai Inst Mental Hlth, Shanghai, Peoples R China
关键词
D O I
10.1038/sj.mp.4001436
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The 8p gene Neuregulin 1, which is one of the glial growth factors expressed during neurodevelopment and in the adult CNS, has recently been identified as a susceptibility gene for schizophrenia by linkage and LD mapping studies in the Icelandic and Scottish population. In the present work, the authors provide independent statistical support for the previous findings that schizophrenia is associated with the 5′ end of the Neuregulin 1 gene.
引用
收藏
页码:11 / 12
页数:2
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