Conceptual and methodological issues in the genetics of mouse agonistic behavior

被引：33

作者：

Maxson, SC

Canastar, A

机构：

[1] Univ Connecticut, Dept Psychol, Storrs, CT 06269 USA

[2] Univ Connecticut, Biobehav Sci Grad Degree Program, Storrs, CT 06269 USA

来源：

HORMONES AND BEHAVIOR | 2003年 / 44卷 / 03期

关键词：

genetics; agonistic behaviors; mice; standardization;

D O I：

10.1016/S0018-506X(03)00137-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Currently, 36 genes have been reported to affect offensive behavior in male mice. Potentially, these genes could be used to analyze the mechanism of this behavior. But there are methodological flies in this conceptual ointment. The studies with these genes varied in the genetic background, the maternal environments, the postweaning housing, the strain or type of opponent, and the type of test. The effects of each of these on the genetics of offense are reviewed with examples. It is concluded that between-study variation in these environmental or experiential circumstances may make it difficult to impossible to relate the effect of one genetic variant to another and to use these to identify and relate the pathways for gene effects on offensive behaviors. For this reason, standardization of these conditions is recommended. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：258 / 262

页数：5

共 43 条

[1]

ADAMS DB, 1980, AGGRESSIVE BEHAV, V6, P295, DOI 10.1002/1098-2337(1980)6:4<295::AID-AB2480060402>3.0.CO

[2]

2-Q

[3]

ADAMS DB, 1979, BEHAV BRAIN SCI, V2, P210

[4]

[Anonymous], GENETIC INFLUENCES N

[5]

Blanchard D. C., 1984, ADV STUDY AGGRESSION, V1, P1

[6]

BLANCHARD DC, 1988, ANNU REV PSYCHOL, V39, P43, DOI 10.1146/annurev.psych.39.1.43

[7]

Campbell PK, 2002, GENETICS, V162, P307

[8]

CARLIER M, 1991, GENETICS, V129, P231

[9] Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase [J].

Chiavegatto, S ;

Dawsons, VL ;

Mamounas, LA ;

Koliatsos, VE ;

Dawson, TM ;

Nelson, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) :1277-1281

[10] Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice [J].

D'Adamo, P ;

Welzl, H ;

Papadimitriou, S ;

di Barletta, MR ;

Tiveron, C ;

Tatangelo, L ;

Pozzi, L ;

Chapman, PF ;

Knevett, SG ;

Ramsay, MF ;

Valtorta, F ;

Leoni, C ;

Menegon, A ;

Wolfer, DP ;

Lipp, HP ;

Toniolo, D .

HUMAN MOLECULAR GENETICS, 2002, 11 (21) :2567-2580

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