The utility of serology in diagnosing candidosis in non-neutropenic critically ill patients

被引:8
作者
Ibàñez-Nolla, J
Torres-Rodríguez, JM
Nolla, M
León, MA
Mèndez, R
Soria, G
Díaz, RM
Marrugat, J
机构
[1] Hosp Gen Catalunya, Intens Care Unit, Barcelona 08190, Spain
[2] Univ Autonoma Barcelona, Hosp Mar, Dept Genet & Microbiol, E-08193 Barcelona, Spain
[3] Hosp Gen Catalunya, Microbiol Lab, Barcelona, Spain
[4] Inst Municipal Invest Med, E-08003 Barcelona, Spain
关键词
Candida glabrata; candidosis; serology; non-neutropenic; ICU;
D O I
10.1046/j.1439-0507.2001.00616.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
This study was carried out to evaluate the utility of serological tests in the diagnosis of candidal infections in non-neutropenic critically ill patients. A prospective study was carried out in a 10-bed general intensive care unit; all patients with at least one organic sample with Candida spp. were included. A therapeutic-diagnostic algorithm was designed, and patients were treated or not, according to a classification. Blood samples were taken, and serological tests included: antigenaemia detection using two different commercial latex kits (Cand-Tec(R) and Pastorex(R)) and antibody detection by indirect haemagglutination (IHA) and indirect germ tube immunofluorescence (IFA). A total of 56% of antibody tests (IHA 45% and IFA 64%) and 26% of antigen tests (Cand-Tec 36% and Pastorex 17%) were positive. The sensitivity and specificity of these tests with respect to systemic candidosis were 37% and 78%, respectively, for antibodies, and 0% and 90% for antigens. There was statistical significance for mortality and low levels of antibodies; Candida glabrata was detected by IFA and Candida tropicalis by Cand-Tec. Serological tests may help to define the prognosis of these patients and to support the detection of specific Candida species.
引用
收藏
页码:47 / 53
页数:7
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