KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection

被引：58

作者：

al Basatena, Nafisa-Katrin Seich ^{[1
]}

MacNamara, Aidan ^{[1
]}

Vine, Alison M. ^{[1
]}

Thio, Chloe L. ^{[2
]}

Astemborski, Jacquie ^{[2
]}

Usuku, Koichiro ^{[3
]}

Osame, Mitsuhiro ^{[4
]}

Kirk, Gregory D. ^{[2
]}

Donfield, Sharyne M. ^{[5
]}

Goedert, James J. ^{[6
]}

Bangham, Charles R. M. ^{[1
]}

Carrington, Mary ^{[7
,8
,9
]}

Khakoo, Salim I. ^{[1
]}

Asquith, Becca ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, London, England

[2] Johns Hopkins Univ, Baltimore, MD USA

[3] Kumamoto Univ, Kumamoto, Japan

[4] Kagoshima Univ, Kagoshima 890, Japan

[5] Rho, Chapel Hill, NC USA

[6] NCI, Rockville, MD USA

[7] SAIC Frederick Inc, NCI Frederick, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD USA

[8] MIT, Ragon Inst MGH, Boston, MA USA

[9] Harvard Univ, Boston, MA 02115 USA

来源：

PLOS PATHOGENS | 2011年 / 7卷 / 10期

基金：

美国国家卫生研究院; 英国惠康基金; 英国医学研究理事会;

关键词：

CELL INHIBITORY RECEPTORS; CD8(+) T-CELLS; NATURAL-KILLER-CELLS; ANTIGEN-CLASS-I; KIR EXPRESSION; DIRECT BINDING; PROVIRAL LOAD; ALLELES; EFFECTOR; POLYMORPHISM;

D O I：

10.1371/journal.ppat.1002270

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.

引用

页数：12

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