学术探索
学术期刊
新闻热点
数据分析
智能评审

D3 receptor expression within the basal ganglia is not affected by Parkinson's disease

被引：40
作者：
Hurley, MJ
Stubbs, CM
Jenner, P
Marsden, CD
机构：
[1] UNIV LONDON KINGS COLL,DIV BIOMED SCI,NEURODEGENERAT DIS RES CTR,PHARMACOL GRP,WARE SG12 0GX,HERTS,ENGLAND
[2] GLAXO GRP RES LTD,WARE SG12 0GX,HERTS,ENGLAND
[3] UNIV LONDON,NATL HOSP NEUROL & NEUROSURG,INST NEUROL,DEPT CLIN NEUROL,LONDON WC1N 3BG,ENGLAND
来源：
NEUROSCIENCE LETTERS | 1996年 / 214卷 / 2-3期
关键词：
dopamine D3 receptor; basal ganglia; Parkinson's disease; in situ hybridization; receptor autoradiography;
D O I：
10.1016/0304-3940(96)12884-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Quantitative receptor autoradiography and in situ hybridization were used to investigate the expression of dopamine D3 receptors in sections of human brain containing limbic (nucleus accumbens) and striatal (caudate nucleus, putamen) regions. High levels of dopamine D3 receptor mRNA and specific [H-3](+/-)7-hydroxy-N,N-di-N-propyl-2-aminotetralin ([H-3]7-OH-DPAT) binding sites were detected in the nucleus accumbens with lower levels in the caudate nucleus and putamen. No difference in D3 receptor expression was observed between normal and parkinsonian brain. These results indicate that D3 receptor expression is not altered in Parkinson's disease. In addition, they suggest that dopamine release in striatal and limbic areas is not necessary for maintenance of D3 receptor expression.
引用
收藏
页码：75 / 78
页数：4
相关论文
共 18 条
[1]   CHANGES IN BRAIN DOPAMINE-RECEPTORS IN MPTP PARKINSONIAN MONKEYS FOLLOWING L-DOPA TREATMENT [J].
ALEXANDER, GM ;
SCHWARTZMAN, RJ ;
GROTHUSEN, JR ;
BRAINARD, L ;
GORDON, SW .
BRAIN RESEARCH, 1993, 625 (02) :276-282
[2]  
BEDARD PJ, 1993, ADV NEUROL, V60, P113
[3]   LOCALIZATION OF DOPAMINE-D3 RECEPTOR MESSENGER-RNA IN THE RAT-BRAIN USING INSITU HYBRIDIZATION HISTOCHEMISTRY - COMPARISON WITH DOPAMINE-D2 RECEPTOR MESSENGER-RNA [J].
BOUTHENET, ML ;
SOUIL, E ;
MARTRES, MP ;
SOKOLOFF, P ;
GIROS, B ;
SCHWARTZ, JC .
BRAIN RESEARCH, 1991, 564 (02) :203-219
[4]   EFFECT OF CHRONIC TREATMENT OF MPTP MONKEYS WITH DOPAMINE D-1 AND OR D-2 RECEPTOR AGONISTS [J].
GAGNON, C ;
BEDARD, PJ ;
DIPAOLO, T .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 178 (01) :115-120
[5]   ALTERATIONS IN STRIATAL AND EXTRASTRIATAL D-1 AND D-2 DOPAMINE-RECEPTORS IN THE MPTP-TREATED COMMON MARMOSET - AN AUTORADIOGRAPHIC STUDY [J].
GNANALINGHAM, KK ;
SMITH, LA ;
HUNTER, AJ ;
JENNER, P ;
MARSDEN, CD .
SYNAPSE, 1993, 14 (02) :184-194
[6]   DIFFERENTIAL EFFECT OF CHRONIC DOPAMINERGIC TREATMENT ON DOPAMINE-D(1) AND DOPAMINE-D(2) RECEPTORS IN THE MONKEY BRAIN IN MPTP-INDUCED PARKINSONISM [J].
GRAHAM, WC ;
SAMBROOK, MA ;
CROSSMAN, AR .
BRAIN RESEARCH, 1993, 602 (02) :290-303
[7]   AUTORADIOGRAPHIC DISTRIBUTION OF D-3-TYPE DOPAMINE-RECEPTORS IN HUMAN BRAIN USING [H-3] 7-HYDROXY-N,N-DI-N-PROPYL-2-AMINOTETRALIN [J].
HERROELEN, L ;
DEBACKER, JP ;
WILCZAK, N ;
FLAMEZ, A ;
VAUQUELIN, G ;
DEKEYSER, J .
BRAIN RESEARCH, 1994, 648 (02) :222-228
[8]   PARKINSONS-DISEASE AND ITS CHEMOTHERAPY [J].
HORNYKIEWICZ, O .
BIOCHEMICAL PHARMACOLOGY, 1975, 24 (10) :1061-1065
[9]  
HURLEY MJ, 1995, BRIT J PHARMACOL, V115, pP29
[10]   Dopamine D-3 receptors in the basal ganglia of the common marmoset and following MPTP and L-DOPA treatment [J].
Hurley, MJ ;
Jolkkonen, J ;
Stubbs, CM ;
Jenner, P ;
Marsden, CD .
BRAIN RESEARCH, 1996, 709 (02) :259-264
12